BEIJING - China Southern Airlines, the country's largest airline in fleet size, is scheduled to begin flying a new route in mid-December from Guangzhou to San Francisco with a stopover in Wuhan.

It will be the fourth service operated by the airline between Guangzhou in south China's Guangdong Province and North America.

There will be three round-trip flights on the route each week, under the flight numbers CZ659 and CZ660. The flights will be undertaken by Boeing 787 Dreamliner, the company said on Friday.

China Southern already flies Guangzhou-Los Angeles, Guangzhou-New York, and Guangzhou-Vancouver.

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